
The Synthetic Control Arm (SCA) Generator by Bayezian is a generative AI system designed to simulate fully synthetic patient cohorts for clinical trials without relying on real-world or legacy data. Through a biologically-grounded pipeline, the system ingests trial protocols, parses eligibility criteria, and synthesises patient profiles that evolve across multi-year virtual timelines. Each patient journey is dynamically informed by peer-reviewed literature from sources like PubMed and DOAJ, ensuring medically plausible outcomes that reflect current standards of care. Ideal for ethically complex, recruitment-constrained, or feasibility-sensitive trials, SCA offers regulators and sponsors an evidence-backed, privacy-preserving alternative to traditional control groups. With the ability to model dropout risks, adverse events, and disease trajectories, it empowers early design optimisation, strategic planning, and investigator readiness long before first patient enrolment.